Ashwagandha Protects Liver Function? - New Hope for Sertraline Users

I'm taking sertraline, but I'm worried about the effect on my liver function... any suggestions?"
."ashwagandha (type of Indian cactus)I would like to know more about the health benefits of especially with drugs.interactionI want to know about."
'Antidepressants.side effectI would like to understand more about the What are some of the latest research findings?"

This article is for those who are interested in this topic.

antidepressantside effectFor those of you who suffer from Have you ever considered the effects of drug therapy on liver function?

Are you aware of the possible effects of long-term administration of the antidepressant sertraline on liver function?

In this article, based on a 2023 study, a possible new hope for sertraline users, the herbashwagandha (type of Indian cactus)This section details the effects of the combination of the two, based on the latest research.

If you are using sertraline and are concerned about its effect on liver function, please read to the end.

What is ashwagandha in the first place?

ashwagandha (type of Indian cactus)(scientific name: Withania somnifera Dunal) has been used for thousands of years in Ayurveda, the traditional medicine of India, to treat both physical and mental health problems.stressThe herb has been used as an effective medicine, tonic, and even aphrodisiac.

Nowadays, the effectiveness of these products has been proven by modern science through various clinical studies, and they are attracting attention.

The fruit is an evergreen shrub of the eggplant family. The name comes from the horse's (ashwa) smell (ganda).
Some say it is named after the robust vigor of horses.

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あわせて読みたい

Contraindications] People who should not take Ashwagandha, and taking it together [side effects]. Spoiler for this article:.ashwagandha (type of Indian cactus)should not be taken mainly by the following people People who overdose People who are pregnant or planning to give birth People with stomach ulcers or gastritis People with diabetes People with autoimmune diseases ....

Paper Outline

The paper presented here is "(Japanese translation).

Introduction.

Background and Objectives of the Study

depressive symptomWidely used to alleviateantidepressant sertralineis highly effective, but in some patients, theAffects liver functionIt is known to exert a

antidepressant sertraline

Sertraline is a drug commonly known as an antidepressant, specifically classified as a "selective serotonin reuptake inhibitor" (SSRI).

Sertraline increases the amount of a neurotransmitter called serotonin in the brain,depressionIt improves symptoms of obsessive-compulsive disorder, panic disorder, social anxiety disorder, and fear disorder.

This drug requires a doctor's prescription, and for someside effectmay occur. Insomnia, nausea, to it,sexual desireDecrease, etc.

In traditional Ayurvedic medicine, a new approach to remedying this situation is tostressThe herb has been used for relief and strengthening,ashwagandha (type of Indian cactus)(Withania somnifera)The study was conducted to explore the usefulness of

The main objectives of this study are,ashwagandha (type of Indian cactus)was to determine the effect of sertraline on liver function in patients taking sertraline.

A brief description of ashwagandha and sertraline

ashwagandha (type of Indian cactus)is an herb that has been used in Ayurveda (a traditional Indian system of medicine) for many years, and its antioxidant,anti-inflammatoryanti-stressThe effect is widely recognized.

On the other hand.sertralineisMainly DepressionSelective serotonin reuptake inhibitors (SSRIs), used in the treatment of depression, relieve depressive symptoms by increasing serotonin levels in the brain.

However, in some patients, long-term use of sertraline may cause changes in liver function.

research methods

Study Design and Participant Selection

This study was conducted byopen label, ,randomization, ,ComparisonandpositiveIt was designed as a study of the newlarge (e.g. serving size)depression80 patients diagnosed with sexual disorders (MDD)participated in the program. The selection of participants was based on specific criteria.

Setting up experimental and control groups

Participants were randomly assigned to two groups.

One is.Group taking sertraline only(cell trailing loop), and the other isSertraline andashwagandha (type of Indian cactus)Groups that use a combination of(Sertraline +)ashwagandha (type of Indian cactus)(Group).

In the latter group,ashwagandha (type of Indian cactus)twice daily for a total of 500 mg (two 250 mg doses).

Study duration and liver function assessment methods

Treatment.3 monthsIt was continued, during which time the liver function of both groups of patients was evaluated.

Specifically, each patient's liver function parameters (SGOT, SGPT, total protein, globulin, etc.) were studied before and after treatment.

SGOT (AST: aspartate aminotransferase)

SGOT (AST: aspartate aminotransferase) is primarily liver as well as heart,muscleThis enzyme is present in tissues such as

When there is liver damage, this enzyme is present in the bloodliquidBecause SGOT is released into the bloodstream, the blood concentration of SGOT isOne indicator reflecting liver healthThe first two are the following.

SGPT (ALT: alanine aminotransferase)

SGPT (ALT: alanine aminotransferase) is another enzyme found in the liver, and like SGOT, it is also found in the blood during liver injury.liquidIt is released into the

Because SGPT is more liver-specific than SGOT,Parameters that more accurately reflect liver functionIt is considered to be a

Total Protein

Total Protein is the amount of protein in the blood.liquidThe total value of the two major proteins in the body, called albumin and globulin.

When total protein levels decrease,May indicate poor liver function or malnutritionThere are

globulin

Globulin is a bloodliquidIt is one of the major proteins present in the body and is involved in the production of antibodies and inflammatory reactions.

If globulin levels are high, the body may have somePossible reaction to infection or autoimmune diseaseIndicates the

findings

Effect of sertraline alone on hepatic function parameters

Sertraline-only groupThe results showed significant increases in SGOT (serum glutamic oxaloacetate transaminase), SGPT (serum glutamic pyruvate transaminase), total protein, and globulin levels in the

On the other hand, there were no significant differences in the values of other liver function parameters.

Effect of co-administration of ashwagandha and sertraline on liver function parameters

On the other hand.ashwagandha (type of Indian cactus)and sertraline in combination groupshowed no significant differences in any of the liver function parameters before and after the 3-month treatment.

Comparison of liver function parameters before and after treatment in both groups

Comparison of liver function parameters in both groups showed that the sertraline alone group had significantly increased levels of SGOT, SGPT, total protein, and globulin, whereas the sertraline alone group had significantly increased levels of SGOT, SGPT, total protein, and globulin,ashwagandha (type of Indian cactus)and sertraline in the combined group, these parameters wereNo significant changes were observed.

From these results, we can conclude thatashwagandha (type of Indian cactus)may prevent changes in liver function when taking sertralineIt was suggested that the

Study Interpretation and Conclusions

Evaluation of the effects of sertraline alone and co-administration with ashwagandha on liver function.

From this study,Sertraline alonewas found to have a significant effect on liver function parameters, especially the levels of SGOT, SGPT, total protein, and globulin.

However, these values areashwagandha (type of Indian cactus)Co-administration withThe results were stable due to

Ashwagandha May Prevent Effects of Sertraline Administration on Liver Function

ashwagandha (type of Indian cactus)and sertraline by co-administration,No significant changes in liver function parametersFrom,ashwagandha (type of Indian cactus)was on sertraline.Possible to prevent effects on liver functionIt is believed that there is a possibility of

I take it that "no change was seen" means that there was very little effect on the liver from sertraline, as there should have been.

Conclusions and recommendations for future research

In conclusion, long-term sertraline administration may increase some liver function parameters, but this isashwagandha (type of Indian cactus)Possibility of preventing this by using a combination ofwas suggested.

However,ashwagandha (type of Indian cactus)and sertraline combination does not affect liver function at all.

These results are,ashwagandha (type of Indian cactus)Further studies to better understand the impact of the combination of sertraline and sertraline on liver functionis required.

summary

How was it? I would like to conclude by summarizing the contents of this article.

That's all for this article. Thank you for reading to the end.

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